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MEC/CCL28 Protein, Mouse

MCE 国际站：MEC/CCL28 Protein, Mouse

MEC/CCL28 Protein, Mouse 是一种 CC 趋化因子，几乎存在于所有粘膜组织中，可作为粘膜表面的统一免疫刺激剂。CCL28 可以与 CCR3 和 CCR10 结合作用，介导免疫反应，病毒感染，癌症以及抗菌作用。MEC/CCL28 Protein, Mouse 一种由 E. coli 表达的重组小鼠 MEC/CCL28 (S20-R130) 蛋白。

Synonyms: rMuMEC/CCL28; C-C motif chemokine 28; SCYA28

Species: Mouse

Source: E. coli

Biological Activity: Determined by its ability to chemoattract CTLL -2 cells. The ED₅₀ for this effect is 1.664 ng/mL, corresponding to a specific activity is 6.01×10^5 U/mg.

研究背景：CCL28, also known as mucosal associated epithelial chemokine (MEC), CCK1, and SCYA28, is a chemokine. It is expressed in various mucosal sites, including salivary glands and mammary glands, trachea and colon, and small intestine. CCL28 has been classified as an important component chemokine in homeostasis lymphocyte transport and can bind to CCR3 and CCR10. Among them, CCL28 can chemotactic CCR10 expression of CD4 and CD8 T cell populations, as well as CCR3 expression of eosinophils migration. However, in the intestinal mucosa, few T cells express CCR10. In contrast, in the B-cell population, CCR10 can be selectively expressed by IgA plasma mother cells and IgA-secreting cells (i.e. plasma cells), which play a key role in homing plasma mother cells to extraintestinal effector sites. CCL28 is constitutively expressed in the colon, but its levels can be increased by pro-inflammatory cytokines and certain bacterial products that play a role in effector cell recruitment to sites of epithelial injury.CCL28 can act as a unifying immunostimulant on the mucosal surface and is involved in the migration of IgA-expressing cells to the breast, salivary glands, intestine, and other mucosal tissues. In addition, CCL28 exhibits broad-spectrum antimicrobial activity against Gram-negative and Gram-positive bacteria as well as fungi, such as Pseudomonas aeruginosa and Klebsiella pneumoniae. Further studies also showed that the positively charged amino acids at the C-terminal end of CCL28 significantly contributed to the antibacterial activity of the protein, and its characteristic hydrophobicity and amphiphilicity also contributed to its killing activity.

蛋白编号：Q9JIL2 (S20-R130)

基因 ID：56838

产品分类：细胞因子和生长因子  |  趋化因子  |  CC 趋化因子  |  趋化因子 CCL28

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CC Chemokines  |  CCL28

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