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IL-4 Protein, Mouse (HEK293)

MCE 国际站：IL-4 Protein, Mouse (HEK293)

IL-4 Protein, Mouse (CHO)是一种 CHO 细胞来源的特异性细胞因子，促进 B 淋巴细胞的增殖，分化和细胞表面蛋白调节。

Synonyms: rMuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

Species: Mouse

Source: HEK293

Biological Activity: Measured in a cell proliferation assay using HT-2 cells. The ED₅₀ this effect is 0.1049 ng/mL, corresponding to a specific activity is 9.533×10^6 units/mg.

研究背景：Mouse Interleukin 4 is a 20-kDa glycoprotein, synthesized by activated T lymphocytes and mast cells, which regulates the growth and/or differentiation of a broad spectrum of target cells of the immune system, including B and T lymphocytes, macrophages, and hematopoietic progenitor cells. Murine Interleukin 4 (IL-4) is a potent mediator of an immune response, affecting both the growth and differentiation of a wide variety of cells in the hematopoietic lineage. This cytokine is expressed by activated T lymphocytes and mast cells as a 20-kDa glycoprotein. The cDNA for IL-4 isinitially is solated by two laboratories, using expression vectors and screening for either a IgG-inducing factor or a mast cell growth factor. The derived amino acid sequence from the cDNA clones is used to predict a protein backbone for IL-4 of 14 kDa. This is consistent with the observation that N-glycanase treatment of natural IL-4, to remove N-linked carbohydrates, yields a protein core of 14 kDa. Initial experiments with deglycosylated native IL-4 and with deglycosylated recombinant IL-4, expressed initially in yeast as a heterogeneous, hyperglycosylated molecule, suggested that the carbohydrate modifications of IL-4 do not affect its ability to bind to receptor and to stimulate T and B cell growth.

蛋白编号：P07750 (H21-S140)

基因 ID：16189

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