MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

FGF-21 Protein, Human (CHO, His)

MCE 国际站：FGF-21 Protein, Human (CHO, His)

FGF-21 Protein, Human (CHO, His)是 CHO 细胞中产生的 C-末端含 His 标签的多肽链。是一种成纤维细胞生长因子 (FGF)，可作为代谢调节剂，具有多重效应。

Synonyms: rHuFGF-21, His; FGF21

Species: Human

Source: CHO

Biological Activity: Measured in a cell proliferation assay using NIH‑3T3 mouse embryonic fibroblast cells. The ED₅₀ for this effect is <5.179 μg/mL in the presence of 1 μg/mL Recombinant Human Klotho beta.

研究背景：Human Fibroblast Growth Factor 21 (FGF21) acts in an endocrine mannerand and is a metabolic regulator with pleiotropic effects. FGF21 possesses protective effects in the cardiovascular system, primarily due to metabolic effects other thanmaintaining energy homoeostasis. FGF21 is also involved inseveral processes, including reducing arteriosclerotic plaque formation in major vessels and protecting themyocardium from injuries caused by infarction, ischaemia-reperfusion, isoproterenol-induced hypertrophy anddiabetic lipotoxicity. In addition, FG2F1 induces these effects by atten-uating remodelling-related inflammation and oxidativestress and promoting myocardial energy metabolism, as well as by preventing lipid- or diabetes-induced cardiaccell apoptosis. FGF21 functions via its interaction with FGF receptors (FGFRs), with the assistance of the co-receptor β-Klotho. Structurally, the FGFRs are divided into four isoforms, FGFR1-FGFR4.

蛋白编号：Q9NSA1 (H29-S209)

基因 ID：26291

产品分类：细胞因子和生长因子  |  FGF 家族  |  成纤维细胞生长因子  |  成纤维细胞生长因子 21

Categories：Cytokines and Growth Factors  |  FGF Family  |  Fibroblast Growth Factor  |  Fibroblast Growth Factor 21 (FGF-21)

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。