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IL-2R alpha/CD25 Protein, Human (HEK293, Fc)

MCE 国际站：IL-2R alpha/CD25 Protein, Human (HEK293, Fc)

IL-2R alpha (CD25) 是高亲和力 IL-2 受体的重要组成部分。IL-2R alpha 增强 IL-2 与其受体复合物的结合，从而调节 T 细胞生长和其他淋巴功能。IL-2R alpha/CD25 Protein, Human (HEK293, Fc) 是一种重组人 IL-2R alpha 蛋白，在 HEK293 细胞中表达，由 192 个氨基酸组成 (E22-C213)，C 末端带有hFc 标签。

Synonyms: rHuIL-2R α/CD25, Fc Chimera; TAC antigen; IL-2-RA; IL-2 R alpha; IL-2Rα; IL2RA

Species: Human

Source: HEK293

Biological Activity: 1. 5 µg/mL (100 µL/well) of immoblized recombinant human IL-2 can bind human CD25/IL-2Rα-Fc with a linear range of 1.2-11 ng/mL.
2. Measured in a cell proliferation assay using Mo7e cells. The ED₅₀ this effect is 0.1982 μg/mL in the presence of 30 ng/mL of recombinant human IL-2, corresponding to a specific activity is 5.05×10^3 units/mg.

研究背景：IL-2R alpha (CD25) is a type I membrane protein. IL-2R alpha is expressed in peripheral activated T and B cells, triple-negative thymocytes, and bone marrow pre-B cells. In high tumor regulatory T (Treg) cells, IL-2R alpha is highly expressed and is a potential target for Treg deletion. The expression of IL-2R alpha is undetectable on resting T cells.
The sequence of amino acids in IL-2R alpha from different species is very different (less than 85% similarity among human, rat and mouse).
IL-2R alpha is an essential component of high-affinity IL-2 receptors and has no signal-transducing activity per se. IL-2R alpha functions through enhancing binding of IL-2 to its receptor complex and acts as a positive feedback regulator. IL-2 is a principal growth factor for T lymphocytes and plays an important role in T cell immune response. IL-2R alpha transcription is regulated by three positive regulatory regions (PRRs): PRRI, PRRII and PRRIII. PRRIII is an IL-2 response element.
IL-2R alpha regulates T cell growth, augments lymphocyte activation and proliferation. IL-2R alpha is involved in preventing type 1 diabetes and cancers.

蛋白编号：P01589 (E22-C213)

基因 ID：3559

产品分类：细胞因子和生长因子  |  白细胞介素  |  白介素-2 受体  |  白介素-2 受体 alpha  |  CD 抗原  |  T 细胞 CD 蛋白  |  CD25/IL-2R alpha  |  CD 抗原  |  B 细胞 CD 蛋白  |  CD25/IL-2R alpha  |  CD 抗原  |  NK 细胞 CD 蛋白  |  CD25/IL-2R alpha

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-2 Receptor  |  IL-2R alpha  |  CD Antigens  |  T Cell CD Proteins  |  CD25/IL-2R alpha  |  CD Antigens  |  B Cell CD Proteins  |  CD25/IL-2R alpha  |  CD Antigens  |  NK Cell CD Proteins  |  CD25/IL-2R alpha

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