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MCE 国际站:BAFFR/TNFRSF13C Protein, Human (Biotinylated, HEK293, His-Avi)
BAFF Receptor (B-cell activating factor receptor,BAFF-R),又名 TNFRSF13C 和BR3,是识别 BAFF 的 TNF 受体超家族的一种膜蛋白。BAFF Receptor 是 B 细胞存活的关键受体,也是 B 细胞和 T 细胞活化的有效共刺激因子。AFFR/TNFRSF13C Protein, Human (Biotinylated, HEK293, His-Avi) 是一种由 HEK293 细胞表达的生物素化的重组蛋白,其 C 末端带有一个 Avi 标签和一个 His 标签,由 65 个 (S7-A71) 氨基酸组成。
Synonyms: CD268; BAFFR; BR3; TNFRSF13C; BROMIX; CVID4; prolixin
Species: Human
Source: HEK293
Biological Activity: Immobilized Anti-BAFFR Antibody at 0.5 ug/ml (100 μL/Well) on the plate. Dose response curve for Biotinylated Human BAFFR, His Tag with the EC50 of 4.4 ng/ml determined by ELISA.
研究背景:BAFF Receptor is expressed on all B cells (except plasma cells), including immature, transitional, mature, memory, and germinal center B cells, as well as on plasma cells, while BAFF-R is also expressed on follicular helper T cells (TFH).
The amino acid sequence of human BAFF Receptor protein has low homology for mouse and rat BAFF Receptor protein.
BAFF Receptor binds to BAFF and recruits TNF receptor-associated factor 3 (TRAF-3) and TRAF-2 to the intracellular domain of BAFF-R molecules. The binding of TRAF3 to the BAFF-R reverses the inhibitory effect of unbound/cytoplasmic TRAF3 on the alternative NF-κB2 signaling pathway. It releases NF-κB-inducing kinase (NIK), which phosphorylates inhibitor of κB kinase 1 (IKK1) leading to activation of non-canonical NF-κB. BAFF-R signaling is critical for peripheral B cell survival and differentiation, germinal center formation, plasma cell survival, and IgG and IgE class switching.
BAFF Receptor binds to BAFF mediates B-cell survival, proliferation, and differentiation, and involves in the formation of GCs in secondary follicles in murine models and tertiary lymphoid structures in autoimmune diseases. BAFF/BAFF-R signaling is crucial for primary B cell survival, differentiation and homeostasis. A/WySnJ mice expressing a defective BAFF-R have disrupted B cell maturation, similar to that seen in BAFF-deficient mice.
蛋白编号:Q96RJ3 (S7-A71)
基因 ID:115650
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子受体 | B-细胞激活因子受体 | CD 抗原 | 巨噬细胞 CD 蛋白 | BAFF R/CD268 | 生物素标记蛋白
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Receptor Superfamily | BAFF Receptor | CD Antigens | Macrophage CD Proteins | BAFF R/CD268 | Biotinylated Proteins
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