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MCE 国际站:FGF-21 Protein, Mouse
FGF-21 Protein, Mouse是一种可参与调节糖、脂、胆汁酸和磷酸盐代谢的代谢激素。
Synonyms: rMuFGF-21; FGF21
Species: Mouse
Source: E. coli
Biological Activity: 1. The ED50 is <0.5 μg/mL as measured by a cell proliferation assay using NIH-3T3 cells in the presence of 1.25 µg/mL mouse Klotho and 10.0 µg/mL heparin, corresponding to a specific activity of >2.0 × 103 units/mg.
2. Measured in a cell proliferation assay using NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 1.001 μg/mL in the presence of 1 μg/mL Recombinant Human Klotho beta, corresponding to a specific activity is 989.12 units/mg.
研究背景:Fibroblast growth factor (FGF) 21 is a member of the FGF superfamily. It is most closely related to FGF19 and FGF23, sharing 30–35% amino acid sequence homology. The FGF19 subfamily comprises FGF19, FGF21, and FGF23, and all three FGF19 subfamily members have recently emerged as metabolic hormones involved in the regulation of glucose, lipid, bile acid, and phosphate metabolism. FGF21 provides sustained glucose and lipid control, amelioration of insulin resistance, improvements in β-cell function and mass, and beneficial changes in other lipoprotein and cardiovascular risk factor profiles.
蛋白编号:Q9JJN1 (A29-S210)
基因 ID:56636
产品分类:细胞因子和生长因子 | FGF 家族 | 成纤维细胞生长因子 | 成纤维细胞生长因子 21
Categories:Cytokines and Growth Factors | FGF Family | Fibroblast Growth Factor | Fibroblast Growth Factor 21 (FGF-21)
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