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MCE 国际站:TPO/Thrombopoietin Protein, Mouse (CHO)
TPO Protein, Mouse (CHO)是一种造血因子,能够控制血小板生长。
Synonyms: rMuTPO; TPO
Species: Mouse
Source: CHO
Biological Activity: The ED50 is <2 ng /mL as measured by MO7e cells.
研究背景:Recombinant thrombopoietin reduces radiation- and chemotherapy-induced thrombocytopenia, enhances platelet recovery after bone marrow transplantation and increases the number of megakaryocyte precursor cells in stem cell harvests. Injection of thrombopoietin into animals stimulates the number, size and ploidy of bone marrow megakaryocytes and increases the platelet count up to ten-fold. Superphysiological amounts of Thrombopoietin/TPO (>100 ng/mL) are able to directly activate platelet aggregation in vitro. Thrombopoietin/TPO also has significant effects on platelet adhesion under flow. Low Thrombopoietin/TPO concentrations (001-1 ng/mL) accelerate firm platelet adhesion to von Willebrand factor and prevent de-attachment at higher flow rates.
蛋白编号:P40226 (S22-T356)
基因 ID:21832
产品分类:细胞因子和生长因子
Categories:Cytokines and Growth Factors
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