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MCE 国际站:FGF-23 Protein, Human
FGF-23 Protein, Human是一种独特的成纤维细胞生长因子 (FGF),它是一种激素,通过辅因子如 α-Klotho 与 FGF 受体结合发挥作用,在软骨形成过程中诱导肥大和矿化的产生。
Synonyms: rHuFGF-23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor
Species: Human
Source: E. coli
Biological Activity: The ED50 is <0.5 μg/mL as measured by FGF-receptors transfected BaF3 cells, corresponding to a specific activity of >2.0 × 103 units/mg.
研究背景:Recombinant Human Fibroblast Growth Factor 23 is a unique FGF subfamily member, acts as a a hormone and requires a cofactor to signal through canonical FGFR, and induces hypertrophy and mineralization during chondrogenesis. FGF23 is a secreted, circulating protein of 32 kDa that is predominantly produced by osteocytesin bone and functions in distant target organs in an endocrine fashion. FGF23 generally requires an FGF receptor (FGFR) and α-Klotho to evoke its signaling. GF23 binds to an FGFR-α-Klotho complex and induces the phosphorylation of FGFR and the expression of early growth response-1 (Egr-1), which encodes a transcription factor.
蛋白编号:Q9GZV9 (Y25-F251)
基因 ID:8074
产品分类:细胞因子和生长因子 | FGF 家族 | 成纤维细胞生长因子 | 成纤维细胞生长因子 23
Categories:Cytokines and Growth Factors | FGF Family | Fibroblast Growth Factor | FGF-23
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