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MCE 国际站:IL-11 Protein, Human (CHO)
IL-11 Protein, Human (CHO)是一种 CHO 细胞来源的保护因子,可以加速血小板恢复,显著降低炎症反应程度,是造血微环境中一个多功能的调节因子。
Synonyms: rHuIL-11; Adipogenesis inhibitory factor; AGIF
Species: Human
Source: CHO
Biological Activity: The ED50 is <5 ng/mL as measured in a proliferation assay by T11 cells.
研究背景:Recombinant Human Interleukin-11 (IL-11) plays a very crucial role in inflammation. Being an essential cytokine, IL-11 promotes chronic gastric inflammation and also associated with STAT3 and STAT1 mediated tumorigenesis. In addition, IL-11 is also an indispensable factor in IL-13- induced Th2-mediated inflammatory disorders and tissue remodeling. IL-11 has diverse biological functions. It has a protective role against neutron radiation injury, capable of promoting a faster recovery of small intestine injuries and also functions in response to inflammation in animal models of infection. Studies have revealed that IL-11 protects animal models of sepsis from liver injuries. Although its role in platelet production in neonates remains unclear, IL-11 is reported to be involved in the endogenous cytokine response to sepsis or Necrotizing Enterocolitis (NEC) in premmies. IL-11 is also involved in NF-κB signaling pathway and inhibition of IL-6 can reduce colitis associated tumorigenesis . Recombinant human interleukin-11 directly promotes megakaryocytopoiesis in vitro.
蛋白编号:P20809 (P22-L199)
基因 ID:3589
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-11
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-11
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