MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
MCE 国际站:CD70 Protein, Cynomolgus (HEK293, His)
CD70 是活化 T 和 B 淋巴细胞上的表面抗原,是 CD27 的配体,参与 CD70-CD27 通路和 T 细胞免疫的产生和维持。CD70 具有抗病毒活性,并调节肿瘤细胞和调节 T 细胞的活力。而来源食蟹猴的 CD70 蛋白含有一个 TNF_2 结构域 (57-189 a.a) 和跨膜螺旋,属于肿瘤坏死因子 (TNF) 家族。重组食蟹猴 CD70 蛋白 (HEK293, His) 全长 156 个氨基酸 (Q39-P194),在 HEK293 细胞中表达,并带有 N 端 His 标签。
Synonyms: CD70 molecule; CD70; TNFSF7; CD27 Ligand; CD27-L; CD27LG; Ki-24 antigen; TNFSF7G
Species: Cynomolgus
Source: HEK293
Biological Activity: Immobilized Cynomolgus CD27 Ligand at 2 μg/mL (100μL/Well) on the plate. Dose response curve for Cynomolgus/Rhesus macaque CD27 with the EC50 of 60.8 ng/mL determined by ELISA.
研究背景:CD70 (CD27 Ligand) belongs to the tumor necrosis factor (TNF) family, is the ligand for TNFRSF27/CD27.
CD70 and CD27 are homotrimer type II and homodimer type I transmembrane glycoprotein, expressing on activated and resting T and B lymphocytes, respectively. CD70 as one of the most frequently mutated genes in a series of diffuse large B cell lymphomas, especially acts in a crucial Epstein-Barr virus (EBV)-specific T cell immunity and more generally for the immune surveillance of B cells. CD70 inhibits EBV infection by restoring the expansion of EBV-specific T lymphocytes stimulated by the CD70-deficient EBV-infected B cells.
CD70 involves in activation of innate and adaptive immunity, expressing in the mature dendritic cells and being up-regulated upon the triggering of CD40 or Toll-like receptors.
CD70 induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation.
CD70 is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. targeting CD70 positive tumors with CAR-T cells induces a potent antitumor response.
蛋白编号:G7PYU6 (Q39-P194)
基因 ID:/
产品分类:CD 抗原 | NK 细胞 CD 蛋白 | CD70 | CD 抗原 | 巨噬细胞 CD 蛋白 | CD70 | 免疫检查点蛋白 | 刺激性免疫检查点 | CAR-T 相关蛋白 | CD70
Categories:CD Antigens | NK Cell CD Proteins | CD70 | CD Antigens | Macrophage CD Proteins | CD70 | Immune Checkpoint Proteins | Stimulatory Immune Checkpoint Molecules | CAR-T related Proteins | CD70
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。