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MCE 国际站:ACE2 Protein, Human (723a.a, HEK293, His)
ACE2 Protein, Human (HEK293, His)是 SARS-CoV-2 的受体。血管紧张素转换酶 2 有效的将 血管紧张素II 水解成血管紧张素。这一结果是 ACE2 参与肾素-血管紧张素系统。
Synonyms: Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
Species: Human
Source: HEK293
Biological Activity: Binding ability is measured by functional ELISA, 10 μg/mL (100 µL/well) of immoblized recombinant human Angiotensin-Converting Enzyme 2, His can bind to S Proetin RBD, C-mFc. The ED50 of S Protein RBD, C-mFc is 19.97 ng/mL.
研究背景:Angiotensin-Converting Enzyme 2 (ACE2) is a type I integral membrane protein which functions as a carboxypeptidase, cleaving a single hydrophobic/basic residue from the C-terminus of its substrates. ACE2 efficiently hydrolyses the potent vasoconstrictor angiotensin II to angiotensin. It is a consequence of this action that ACE2 participates in the renin-angiotensin system. However, ACE2 also hydrolyses dynorphin A (1–13), apelin-13 and des-Arg9 bradykinin. The role of ACE2 in these peptide systems has yet to be revealed. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. This paper reviews the biochemistry of ACE2 and discusses key findings such as the elucidation of crystal structures for ACE2 and testicular ACE and the development of ACE2 inhibitors that have now provided a basis for future research on this enzyme.
蛋白编号:Q9BYF1 (Q18-S740)
基因 ID:59272
产品分类:酶和调节子 | 血管紧张素转换酶 | 血管紧张素转换酶 2 | 酶和调节子 | 水解酶
Categories:Enzymes & Regulators | Angiotensin-converting Enzymes | Angiotensin-Converting Enzyme 2 (ACE2) | Enzymes & Regulators | Hydrolases (EC 3)
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