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IL-20R alpha Protein, Mouse (HEK293, Fc)

MCE 国际站：IL-20R alpha Protein, Mouse (HEK293, Fc)

IL-20R alpha 蛋白 (IL20RA) 是 IL-20 受体的 α 亚基，与不同亚基蛋白形成功能性异二聚体，参与 STAT3 通路激活。IL20RA/IL20RB 二聚体是 IL-19、IL-20 和 IL-24 的受体，而 IL20RA/IL10RB 二聚体是 IL-26 的受体。IL-20R alpha 蛋白由 553 个氨基酸 (M1-N553) 组成，具有跨膜结构域 (254-274 a.a.)。重组小鼠 IL-20R alpha 蛋白 (250a.a, HEK293, His)，由 HEK293 细胞表达，带有 C 末端 His 标签。

Synonyms: IL-20R-alpha; IL-20RA; CRF2-8; IL-20R1; ZcytoR7; FLJ40993

Species: Mouse

Source: HEK293

Biological Activity: Mouse IL-20RA, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-20, His Tag with an affinity constant of 13.93 μM as determined in SPR assay (Biacore T200).

研究背景：IL-20R alpha, also known as a alpha subunit of IL-20 receptor (IL-20RA), belongs to the type II cytokine receptor family.
IL-20R alpha is widely expressed with highest levels in skin and testis and high levels in brain.
IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes.
IL-20R alpha forms functional heterodimers with different subunit protein. IL-20R alpha serves as the receptor for IL-19, IL-20 and IL-24 by dimerizing with IL20RB, however serves as the receptor for IL-26 by dimerizing with IL-10RB. IL-20R alpha transduces ligand-binding at least in part through STAT3 activation, and plays an important role in epidermal function and psoriasis.
The sequence of amino acids in IL-12 beta proteins of mouse is very different from human (64.64%).

蛋白编号：Q6PHB0 (V33-K253)

基因 ID：237313

产品分类：细胞因子和生长因子  |  白细胞介素  |  白介素-20 受体  |  白介素-20 受体 α

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-20 Receptor  |  IL-20R alpha

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