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OSM Protein, Human (227a.a)

MCE 国际站：OSM Protein, Human (227a.a)

OSM Protein, Human (227a.a)是由 227 个氨基酸组成的多肽链。OSM是属于IL-6家族的细胞因子，其在造血，间充质干细胞分化，肝再生，心脏重塑，痛觉，炎症和代谢中具有多种功能。

Synonyms: rHuOSM; OSM

Species: Human

Source: E. coli

Biological Activity: The ED₅₀ is <10 ng/mL as measured by human TF-1 cells, corresponding to a specific activity of >5.0 × 10⁵ units/mg.

研究背景：Oncostatin M is a cytokine belonging to the IL-6 family that has multiple functions in hematopoiesis, mesenchymal stem cell differentiation, liver regeneration, heart remodeling, nociception, inflammation and metabolism. The full-length Oncostatin M proteins contain between 239 and 263 amino acids which fold into a long-chain four helix-bundle protein with an up-up-down-down topology representative of all other IL-6 family cytokines. Human Oncostatin-M can bind to either the type I receptor complex consisting of gp130 and the LIFR (gp130/LIFRb) or the type II receptor complex consisting of gp130 and the OSMR (gp130/OSMRb). In the murine system Oncostatin-M has been shown to bind with high affinity only to the type II gp130/OSMRb complex. Oncostatin-M binds to specific receptor complexes, then activates two major signaling pathways: Janus Kinase-Signal Transducers and Activators of Transcription (JAK-STAT) and Mitogen-Activated Protein Kinase (MAPK), to regulate downstream events.

蛋白编号：P13725 (A26-R252)

基因 ID：5008

产品分类：细胞因子和生长因子

Categories：Cytokines and Growth Factors

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