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IL-4 Protein, Mouse (HEK293, His)

MCE 国际站：IL-4 Protein, Mouse (HEK293, His)

IL-4 Protein, Mouse (HEK293, His)是一种多效性细胞因子，可调节多种 T 和 B 细胞反应，包括细胞增殖、存活和基因表达。IL-4, Mouse (HEK293, His) 是一种在 HEK 293 细胞中表达的，末端有 His 标签的重组小鼠白细胞介素-4 (rhIL-4)。

Synonyms: Interleukin-4; IL-4; IL4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; Lymphocyte stimulatory factor 1

Species: Mouse

Source: HEK293

Biological Activity: Measured in a cell proliferation assay using M-NFS-60 mouse lymphoblast cells. The ED₅₀ for this effect is <80 pg/mL.

研究背景：IL-4 is a T cell-derived growth factor for B cells. In addition to T cells, IL-4 is produced by innate lymphocytes, such as NTK cells, and myeloid cells, such as basophils and mast cells. It is a signature cytokine of type 2 immune response but also has a nonimmune function. Its expression is tightly regulated at several levels, including signaling pathways, transcription factors, epigenetic modifications, microRNA, and long noncoding RNA. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4⁺ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy.

蛋白编号：P07750 (H21-S140)

基因 ID：16189

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-4

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-4

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