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MCE 国际站:IL-1 beta Protein, Mouse (CHO)
IL-1 beta 是一种强效促炎细胞因子,由单核细胞、巨噬细胞和树突状细胞表达,在炎症和免疫反应中起关键作用。IL-1 beta 以无活性的 pro-IL-1β (由 pro-Il-1b 编码) 形式产生,以响应炎症刺激。IL-1 beta Protein, Mouse (CHO) 由 CHO 细胞表达产生,由 152 个氨基酸 (V118-S269) 组成。
Synonyms: rMuIL-1β; Catabolin; IL1F2; IL-1 beta; IL1B
Species: Mouse
Source: CHO
Biological Activity: The ED50 is <10 pg/mL as measured by D10S cells, corresponding to a specific activity of >1 × 108 units/mg.
研究背景:Interleukin-1β (IL-1β) is one of the pro-inflammatory cytokines and is produced and secreted by a variety of cell types although the vast majority of studies have focussed on its production within cells of the innate immune system, such as monocytes and macrophages.
IL-1β is produced as inactive pro-IL-1β (encoded by pro-Il-1b) in response to inflammatory stimuli, including both microbial products and endogenous danger-associated molecules. IL-1β gene expression and synthesis of pro-IL-1β occurs after activation of pattern recognition receptors (PRRs). Inflammatory stimuli also drive activation of cytosolic CARD and PYHIN domain-containing PRRs that recruit ASC and caspase-1 (Casp-1) to assemble into the multiprotein complex inflammasome. Pro-Casp-1 (encoded by pro-Casp-1), activated by the inflammasome, cleaves pro-IL-1β into the bioactive IL-1β. IL-1β acts in an autocrine/paracrine manner via the type I IL-1 receptor (IL-1R1).
IL-1β could regulate the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. IL-1β also plays a significant regulator of reproduction in females.
蛋白编号:P10749 (V118-S269)
基因 ID:16176
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-1 | 白细胞介素-1 beta | 细胞因子和生长因子 | 神经营养因子 | 白细胞介素-1 | 白细胞介素-1 beta
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-1 | IL-1 beta | Cytokines and Growth Factors | Neurotrophic Factors | IL-1 | IL-1 beta
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