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SDF-1 beta/CXCL12 Protein, Mouse

MCE 国际站：SDF-1 beta/CXCL12 Protein, Mouse

SDF-1 beta (基质衍生因子-1β，SDF-1β) 是一种基质衍生的 CXC 趋化因子，通过 CXCR4 受体发出信号。SDF-1β 对 B 和 T 细胞具有趋化活性。SDF-1 beta/CXCL12 Protein, Mouse 在大肠杆菌中表达产生，由 72 个氨基酸(K22-M93) 组成。

Synonyms: C-X-C motif chemokine 12; Stromal cell-derived factor 1; CXCL12; SDF-1β

Species: Mouse

Source: E. coli

Biological Activity: 1. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 50-100 ng/ml.
2. Measured in a cell proliferation assay using Jurkat cells. The ED50 this effect is 2.589 ng/mL, corresponding to a specific activity is 3.86×10^5 units/mg.

研究背景：The chemokine stromal-derived factor-1 (SDF-1), which is constitutively expressed in most tissues as SDF-1α and SDF-1β resulting from alternative gene splicing, regulates hematopoiesis, lymphocyte homing, B-lineage cell growth, and angiogenesis. SDF-1β is assigned to the intercrine cytokine family (chemokines) which is characterized by four conserved cysteines that form two disulfide bonds. Furthermore its expression is found in all organs except in blood cells.
SDF-1β which is virtually the same as SDF-1α, except in that the fourth exon consists of only four residues attached to a C-terminus, shows very similar activity in vitro and in tissues, but is twice as potent in the blood. SDF-1α comprises 3 exons and encodes a protein of 89 amino acids whereas SDF-1β consists of 4 exons and encodes a protein of 93 amino acids. Both isoforms are highly similar regarding their sequences with the only difference of 4 additional amino acids at the C-terminus of SDF1β. In addition, SDF-1β is shown to be a sufficient factor capable of supporting rodent B-cell lymphopoiesis. SDF-1β is expressed less abundantly and seems to be related to the vascular system. Its greater resistance to proteolysis within the blood predispose it to this role.
Endothelial cells of cerebral microvessels in mice express SDF-1β selectively. Its upregulation is found following focal cerebral ischemia and is associated with the infiltration of CXCR4-expressing peripheral blood cells, such as macrophages. SDF-1β also has a greater effect on angiogenesis in human microvascular endothelial cells (HMEC). Compared with SDF-1α, SDF-1β is more resistant to blood-dependent degradation, stimulates angiogenesis and is present in highly vascularized organs such as: the liver, spleen and kidneys.

蛋白编号：P40224-2 (K22-M93)

基因 ID：20315

产品分类：细胞因子和生长因子  |  趋化因子  |  CXC 趋化因子  |  CXC 趋化因子配体 12  |  趋化因子  |  CXC 趋化因子  |  CXC 趋化因子配体 12  |  CXCL12/SDF-1 beta

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CXC Chemokines  |  SDF-1/CXCL12  |  Chemokine & Receptors  |  CXC Chemokines  |  SDF-1/CXCL12  |  CXCL12/SDF-1 beta

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