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MCE 国际站:IL-3 Protein, Human (133a.a, HEK293, His)
IL-3 Protein, Human (133a.a, HEK293, His)是一种多能造血生长因子,可用于改善造血衰竭状态。IL-3, Human (HEK293, His) 是一种在 HEK 293 细胞中表达的,末端有 His 标签的重组人白细胞介素-3 (rhIL-3)。rhIL-3 也是一种弱炎症介质。
Synonyms: Interleukin-3; IL-3; Hematopoietic Growth Factor; Mast Cell Growth Factor; MCGF; Multipotential Colony-Stimulating Factor; P-Cell-Stimulating Factor; IL3
Species: Human
Source: HEK293
Biological Activity: The cell proliferation assay using TF-1 human erythroleukemic cells has an ED50 value of 0.3-1.5 ng/mL.
研究背景:IL-3 has growth- and differentiation inducing potential on cells of the erythroid, granulocyte-macrophage (GM), megacaryocyte, and mast-cell lineage in vitro.
In addition IL-3 enhances the function of mature myeloid effector cells by stimulating monocyte- and eosinophil-mediated phagocytosis and antibody-dependent cellular cytotoxicity (ADCC), monocyte M-CSF receptor expression, tumor necrosis factor (TNF) and M-CSF synthesis, and basophil production of intracellular histamine and its release in response to complement factor C5a.
Thus, IL-3 may serve as a recruitment factor for activated inflammatory cells in states of increased demand, rather than being a major regulatory element in steady-state hematopoiesis.
蛋白编号:P08700 (A20-F152)
基因 ID:3562
产品分类:细胞因子和生长因子 | 集落刺激因子 | 多能集落刺激因子
Categories:Cytokines and Growth Factors | CSF & Receptors | Multi-CSF/IL-3
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