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MCE 国际站:IFN-alpha 13/IFNA1 Protein, Human
IFN-alpha 13 (IFNA13) 属于 I 型干扰素家族,由巨噬细胞产生而具有抗病毒活性。重组人 IFN-alpha 13/IFNA1 蛋白含有 166 个氨基酸 (C24-D189),由 E. coli 细胞产生,不带标签。
Synonyms: Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1; IFNA13
Species: Human
Source: E. coli
Biological Activity: The specific activity determined by an anti-viral assay is no less than 1.0 × 108 IU/mg.
研究背景:IFN-alpha 13 (IFNA13; IFN-α13) is produced by the macrophages, belongs to the alpha/beta interferon (IFN) family, a family of cytokines induced by viral infection and are primarily involved in antiviral defense of the cells. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively.
Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia.
IFN-alpha13 exhibits acid-stable antiviral activity against Theiler's virus, Mengo virus, and vesicular stomatitis virus. Firstly, it is transcribed constitutively, independent of viral infection and of interferon regulatory factor-7 induction. Secondly, it contains two N-glycosylation sites, in contrast to other murine IFN-alpha subtypes that contain either one or no N-glycosylation site. As for a wildly use of IFN in animal model, the sequence of amino acids in IFNA13 protein of human is very different from mouse (64.55%)
蛋白编号:P01562 (C24-E189, A137V)
基因 ID:3439
产品分类:细胞因子和生长因子 | 干扰素 | 干扰素 α | 干扰素 α13
Categories:Cytokines and Growth Factors | Interferon & Receptors | IFN-alpha | IFN-alpha 13
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