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CAS No. : 959-23-9
MCE 国际站:4'-Methoxychalcone
产品活性:4'-Methoxychalcone 通过 PPARγ 活化调节脂肪细胞分化,并调节参与胰岛素敏感性的脂肪组织中各种脂肪因子的表达和分泌。
研究领域:Cell Cycle/DNA Damage | Epigenetics
作用靶点:PARP
结构分类:黄酮类 | 查耳酮
来源:植物 | 胡椒科 | 胡椒
In Vitro: 4'-Methoxychalcone (5 μM; 8 days) markedly increases the mRNA expression of adipogenic genes during adipocyte differentiation, PPARγ, aP2, FAS, adiponectin and GluT 4.4'-Methoxychalcone (5 μM; 8 days) reduces the upregulated mRNA expression of IL-6, PAI-1, and MCP-1 by TNF-α in preadipocyte 3T3-L1 cells.4'-Methoxychalcone (5 μM; 0-8 days) causes an increase in PPARγ expression during differentiation, while C/EBPβ protein expression is relatively unaffected.
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