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Licochalcone B

CAS No. : 58749-23-8

MCE 国际站：Licochalcone B

产品活性：Licochalcone B 是从 Glycyrrhiza uralensis 根中提取的。Licochalcone B 抑制淀粉样蛋白 β (amyloid β; Aβ₄₂) 自聚集作用 (IC₅₀=2.16 μM) 并分解预先形成的 Aβ₄₂ 原纤维，通过螯合金属离子减少金属诱导的 Aβ₄₂ 聚集。Licochalcone B 在 LPS 信号通路中抑制 NF-κB p65 磷酸化。Licochalcone B 可抑制 NSCLC 细胞的生长并诱导凋亡。Licochalcone B 通过破坏 NEK7‐NLRP3 相互作用来抑制 NLRP3 炎症小体。

研究领域：Neuronal Signaling  |  Apoptosis  |  Immunology/Inflammation

作用靶点：Amyloid-β  |  Apoptosis  |  NOD-like Receptor (NLR)

结构分类：黄酮类  |  查耳酮

来源：植物  |  豆科  |  甘草

In Vitro: Licochalcone B (IC₅₀: 2.16 μM) inhibits self-mediated Aβ42 aggregation and disaggregates Aβ42 pre-formed fibrils.
Licochalcone B (0-12 μM, 48 h) reduces the ROS generation and protects cells from H₂O₂-induced cell death in SH-SY5Y cells.
Licochalcone B (10 μM, 1 h) inhibits LPS-induced NF-κB activation in RAW264.7 cells.
Licochalcone B (10 μM, 1 h) inhibits the LPS-induced phosphorylation of NF-κB p65 at serine 276, and inhibited the expression of TNFα and MCP-1.
Licochalcone B (0-20 μM, 24 or 48 h) inhibits human NSCLC cell growth.

In Vivo: Licochalcone B (1-25 mg/kg, oral gavage) alleviates oxidative stress of hepatotoxicity in mice induced by CCl₄.

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