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CAS No. : 520-11-6
MCE 国际站:Nepetin
产品活性:Nepetin (6-Methoxyluteolin) 是从 Eupatorium ballotaefolium HBK 分离的天然类黄酮,具有有效的抗炎活性。Nepetin 在 ARPE-19 细胞中抑制 IL-6,IL-8 和 MCP-1 分泌,IC50 值分别为 4.43 μM、3.42 μM 和 4.17 μM。
研究领域:Immunology/Inflammation
作用靶点:Interleukin Related
结构分类:黄酮类 | 黄酮 | 酚类 | 多酚类
来源:植物 | 菊科 | Eupatorium ballotaefolium | 植物 | 菊科 | 甜叶菊 | 植物 | 唇形科
In Vitro: Pretreatment with Nepetin dose-dependently inhibited IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43, 3.42 and 4.17 μM, respectively.
Nepetin (2.5-10 μM; 25 hours; ARPE-19 cells) treatment suppresses IL-1β-induced cytokine (IL-6, IL-8 and MCP-1) expression at mRNA level in ARPE-19 cells.
Nepetin (2.5-10 μM; 1.5 hours; ARPE-19 cells) treatment dose-dependently inhibits phosphorylation of IKKα/β and IκBα, and nuclear translocation of p65. Nepetin decreases the level of phosphorylated ERK1/2, JNK and p38 MAPK in activated ARPE-19 cells.
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货号: HY-N2572
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