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Camalexin

CAS No. : 135531-86-1

MCE 国际站：Camalexin

产品活性：Camalexin 是一种植物抗毒素，是从 Camelina sativa （十字花科植物）中分离出来的，具有抗菌，抗真菌，抗增殖和抗癌活性。Camalexin 可诱导活性氧 (ROS) 的产生。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Reactive Oxygen Species  |  Fungal  |  Bacterial

结构分类：生物碱  |  吲哚类生物碱  |  结构分类

来源：植物  |  十字花科  |  亚麻荠

In Vitro: Camalexin shows antiproliferative activity against a human breast cancer cell line.
For the oomycetes Phytophthora and Pythium Nep1-like proteins (necrosis and ethylene-inducing peptide 1-like proteins) are the initial triggers of Camalexin synthesis and formation of reactive oxygen species (ROS). ROS appear to be of general relevance for Camalexin formation. Chemical induction of ROS, such as by application of acifluorfen, coincided with Camalexin synthesis. In a screen for enhanced susceptibility to Alternaria brassicicola the esa1 mutant is identified, which shows delayed Camalexin induction. Particularly in response to ROS inducing agents reduced Camalexin levels are synthesized. This crucial role for ESA1 is confirmed by the inability of esa1 mutants to synthesize Camalexin in response to Leptosphaeria maculans. An additional mutant that exhibits greatly reduced Camalexin accumulation is ups1, which is isolated on the basis of diminished expression of a tryptophan biosynthetic enzyme.

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