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CAS No. : 86361-55-9
MCE 国际站:Gnetol
产品活性:Gnetol 是从 Gnetum montanum 的根中分离出来的酚类化合物。Gnetol 有效抑制 COX-1 (IC50 为 0.78 μM) 和 HDAC。Gnetol 是一种有效的酪氨酸酶抑制剂,对鼠酪氨酸酶的 IC50 为 4.5 μM,可抑制黑色素的生物合成。Gnetol 具有抗氧化,抗增殖,抗癌和保肝活性。Gnetol 还具有浓度依赖性的 α-淀粉酶,α-葡萄糖苷酶和脂肪形成活性。
研究领域:Immunology/Inflammation | Metabolic Enzyme/Protease | Cell Cycle/DNA Damage | Epigenetics
作用靶点:COX | Tyrosinase | HDAC
结构分类:酚类 | 多酚类 | 二苯乙烯类 | 结构分类
来源:植物 | 买麻藤科 | 买麻藤
In Vitro: The antiproliferative activities of Gnetol are tested in HCT-116, Hep-G2, MDA-MB-231, and PC-3 cell lines by measuring cell viability after treatment with 4.1 μM, 40.9 μM, 204.7 μM, 409.4 μM, and 1023.6 μM. Gnetol shows concentration-dependent reductions in cell viability in cancer cell lines with greatest activity in colorectal cancer.
Gnetol at 200 µg/mL significantly offers the highest protection of 54.3% against the toxicant. A lower dose of Gnetol (50 µg/mL) also shields the cell line from the toxic effects of CCl4.
The ligand molecule TGF-β and PPARα protein show that Gnetol has the binding affinity of 7.0 and 8.4, respectively.
In Vivo: Male Sprague-Dawley rats were cannulated and dosed either intravenously with Gnetol (10 μg/kg) or orally (100 mg/kg). After oral and intravenous administration, Gnetol is detected in both serum and urine as the parent compound and as a glucuronidated metabolite. The bioavailability of Gnetol is determined to be 6%. Gnetol is rapidly glucuronidated and is excreted in urine and via nonrenal routes.
Pretreatment of Male NIH Swiss mice (20-35 g) with Gnetol (50mg/kg, SC) is able to increase the latency period to response in analgesia models.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Phenols Library | Traditional Chinese Medicine Active Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Obesity Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Natural Product Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Osteogenesis Compound Library | Highly Selective Inhibitors Library | Meloxicam-d3-1 | YF479 | 4-Methylamino antipyrine hydrochloride | Vedaprofen-d3 | Pelubiprofen-13C,d3 | Flanvotumab | N-tert-Butyl-α-phenylnitrone-d14 | KD 5170 | Tepoxalin | (R)-Trolox | HDAC-IN-48 | Ampyrone | Pectolinarigenin | Ermanin | Aceclofenac-d4 | SC-58125 | Remetinostat | HDAC-IN-30 | Salicylic acid-13C6 | (±)-Naproxen-d3-1 | HDAC-IN-52 | Dehydroevodiamine hydrochloride | Tyrosinase-IN-5 | Aspirin-d4 | CG347B | XMD16-5 | Psammaplin A | JPS016 | HDAC6-IN-9 | Asaraldehyde
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货号: HY-126052
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