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Rhapontigenin

CAS No. : 500-65-2

MCE 国际站：Rhapontigenin

产品活性：Rhapontigenin 是白藜芦醇的天然类似物，具有抗癌，抗氧化剂，抗真菌和抗菌活性。 Rhapontigenin 是强效选择性细胞色素 P450 1A1 抑制剂 (IC₅₀=400 nM)。Rhapontigenin 对 P450 1A1 的选择性分别是 P450 1A2 和 P450 1B1 的 400 和 23 倍。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Cytochrome P450  |  Fungal  |  Bacterial

结构分类：酚类  |  多酚类  |  二苯乙烯类

来源：植物  |  豆科  |  胡卢巴

In Vitro: Rhapontigenin (0-250 μM; 24 hours) demonstrates concentration-dependent anti-cancer activity with an IC₅₀ 115μM in HEP G2 cells.
Rhapontigenin (20 μM; 20 hours) pre-treatment decreases TGF-β triggered increased snail expression in diverse cancer cells.
Rhapontigenin (0-20 μM; 6 hours) inhibits TGF-β-induced expression of N-cadherin, vimentin, and CA9 in a dose-dependent manner.
Rhapontigenin inhibits ADP- and collagen-induced platelet aggregation with IC₅₀ values of 4 and 70 μg/ml, respectively.
Rhapontigenin demonstrates a strong inhibitory activity on the 13-hexosaminidase release induced by DNP-BSA, it exhibits IC₅₀ value of 0.03 mM in RBL 2H3 cells.

In Vivo: Rhapontigenin (intraperitoneal injection; 25mg/kg) shows significant protection from death due to pulmonary thrombosis in mice, those samples are orally administered 90 min before tail vein injection of epinephrine and collagen.

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