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CAS No. : 238074-03-8
MCE 国际站:Hyperforin dicyclohexylammonium salt
产品活性:贯叶金丝桃素二环己基铵盐 (Hyperforin DCHA) 是瞬时受体典型 6 (TRPC6) 通道激活剂。Hyperforin dicyclohexylammonium salt 通过激活 Ca2+ 传导非选择性典型 TRPC6 通道来调节 Ca2+ 水平。Hyperforin dicyclohexylammonium salt 还表现出多种药理活性,包括抗抑郁、抗肿瘤、抗痴呆、抗糖尿病等。Hyperforin dicyclohexylammonium salt 调节 γδ T 细胞分泌 IL-17α,改善Imiquimod (HY-B0180) 诱导的银屑病样小鼠皮肤炎症。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点:TRP Channel | Calcium Channel
结构分类:其他类 | 结构分类
来源:植物 | 藤黄科 | 贯叶连翘
In Vitro: Hyperforin dicyclohexylammonium salt has a multi-directional mechanism of action. It blocks conductance of ligand-gated (GABA, NMDA, and AMPA receptors) and voltage-gated channels (Ca2+, K+, and Na+).
Hyperforin dicyclohexylammonium salt (0.1, 1, 10 μM; 2 h) reduces the expression and secretion of IL-17A in γδ T cell in vitro cultured murine splenic γδ T cells.
Hyperforin dicyclohexylammonium salt (0.1, 1, 10 μM; 2 h) suppresses phosphorylation of MAPK and STAT3 pathways in TNF-α stimulated HaCaT cells.
Hyperforin dicyclohexylammonium salt (IC50=3.7 μmol/L) inhibits the microvascular tube formation and proliferation of HDMEC in a dose-dependent manner without toxic effects.
In Vivo: Hyperforin dicyclohexylammonium salt (5 mg/kg; i.p.; once daily for 7 d) ameliorates Imiquimod (HY-B0180)-induced psoriatic skin lesion in mice, as well as inhibiting inflammatory cell infiltration and inflammatory cytokines release.
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