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Isoliquiritin apioside

CAS No. : 120926-46-7

MCE 国际站：Isoliquiritin apioside

产品活性：Isoliquiritin apioside 显著降低了 PMA 诱导的 MMP9 活性增加，并抑制了 PMA 诱导的 MAPK 和 NF-κB 活化。Isoliquiritin apioside 抑制癌细胞和内皮细胞的侵袭和血管生成。

研究领域：NF-κB  |  Metabolic Enzyme/Protease  |  MAPK/ERK Pathway

作用靶点：NF-κB  |  MMP  |  p38 MAPK

结构分类：黄酮类  |  查耳酮  |  酚类  |  多酚类

来源：植物  |  其他科

In Vitro: Isoliquiritin apioside efficiently suppresses the PMA-induced gelatinolytic MMP-9 activity in HT1080 cells. Isoliquiritin apiosidealso decreases the PMA-induced increase in MMP-9 production in HT1080 cells.Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and endothelial cells (ECs), with no cytotoxicity.

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