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Nootkatone

CAS No. : 4674-50-4

MCE 国际站：Nootkatone

产品活性：Nootkatone，来自于 Vitis vinifera 的神经保护剂，具有抗氧化和抗炎作用。Nootkatone 可改善脂多糖诱导的阿尔茨海默氏病小鼠模型的认知障碍。

研究领域：Others

作用靶点：Others

结构分类：萜类  |  倍半萜

来源：植物  |  葡萄科  |  葡萄

In Vivo: Nootkatone (10 mg/kg) group shows good performance in behavior experiments including Y-maze test and Morris water maze test. The results of histopathological examination and immunohistochemical analysis showed that LPS induced degeneration of neurons and activation of microglia particularly in hippocampus and Nootkatone (10 mg/kg) reversed these changes. Enzyme linked immunosorbent assay and western blot analysis also demonstrated that the model group had increased expression of IL-1β, IL-6, TNF-α, NLRP3 and NF-κB p65, especially in hippocampus relative to sham-operated group, and Nootkatone (10 mg/kg) decreased the high expression of these inflammatory cytokines.

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货号: HY-N2195

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