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CAS No. : 13220-57-0
MCE 国际站:Tryptanthrin
产品活性:Tryptanthrin 是一种吲哚喹唑啉,可以是产自靛蓝植物的生物碱。Tryptanthrin 是一种口服有效的细胞白三烯 (LT) 生物合成抑制剂。Tryptanthrin 具有抗癌活性。Tryptanthrin 可抑制 NOS1、COX-2、NF-κB 的表达水平,调节 IL-2、IL-10、TNF-α 的表达水平。
研究领域:GPCR/G Protein | Immunology/Inflammation | NF-κB | Apoptosis
作用靶点:Leukotriene Receptor | NO Synthase | NF-κB | COX | TNF Receptor | Interleukin Related
结构分类:生物碱 | 吲哚类生物碱 | 结构分类
来源:植物 | 蓼科 | 蓼蓝
In Vitro: Tryptanthrin (0-60 μM; 24, 48 and 72 h) inhibits the proliferation and colony formation of MCF-7 cells.
Tryptanthrin (6.25-25 μM; 48 h; MCF-7 cells) reverses EMT-associated E-cadherin, MMP-2 and Snail.
Tryptanthrin (0-30 μM; 15 min; MCF-7 cells) reduces Leukotriene (LT)-formation in human neutrophils with an IC50 value of 0.6 μM.
In Vivo: Tryptanthrin (25-100 mg/kg; i.g.; daily, for 13 d; Female Bal b/c mice with 4T1 xenograft) inhibits tumor growth and regulates IL-2, IL-6, IL-10, IL-12 and TNF-α levels in tumor-bearing mice.
Tryptanthrin (10 mg/kg; p.o.; male Wistar Han rats) inhibits LTB4 formation in vivo.
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