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Silymarin

CAS No. : 65666-07-1

MCE 国际站：Silymarin

产品活性：Silymarin 是水飞蓟 (Silybum marianum) 的提取物。Silymarin 是一种有效的 SARS-CoV-2 主蛋白酶 (M^pro) 抑制剂。Silymarin 可以显着降低肿瘤细胞的增殖，血管生成以及胰岛素抵抗。Silymarin 对于肝细胞癌 (HCC) 具有化学预防作用。Silymarin 具有用于 COVID-19 研究的潜力。

研究领域：Anti-infection

作用靶点：SARS-CoV

结构分类：其他类  |  结构分类

来源：植物  |  豆科  |  Glycine soya  |  植物  |  豆科  |  瓜儿豆  |  植物  |  菊科

In Vitro: Silymarin (0-120 μg/ml; 24 hours) inhibits AGS cell viability, the viability of AGS cells is 77.9% in the presence of 20 μg/ml silymarin, 71.5% at 40 μg/ml, 59.8% at 60 μg/ml, 44.5% at 80 μg/ml, 35.3% at 100 μg/ml and 33.9% at 120 μg/ml.
Silymarin (40-80 μg/ml; 24 hours) inhibits the migration of the AGS cells in a concentration-dependent manner. It inhibit migration of AGS cells 59.4% at 40 μg/ml and 21.7% at 80 μg/ml,respectively.

In Vivo: Silymarin (oral gavage; 10, 20, 50, 100, and 200 mg/kg) decreases the immobility time in a dose-dependent manner in forced swimming test (FST). It also lowers the immobility measure dose-dependently in tail suspension test (TST). Additionally, 50% of maximum response (ED₅₀) of Silymarin is around 10 mg/kg. The dose 100 mg/kg proved the most effective dose in both the tests.

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