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Tenuifoliside A

CAS No. : 139726-35-5

MCE 国际站：Tenuifoliside A

产品活性：Tenuifoliside A 分离自远志，具有抗凋亡和抗抑郁作用。在 C6 细胞中，Tenuifoliside A 表现出其神经营养作用，并通过 ERK/CREB/BDNF 信号通路促进细胞增殖。

研究领域：MAPK/ERK Pathway  |  Stem Cell/Wnt

作用靶点：ERK

结构分类：萜类  |  三萜  |  酚类  |  单酚类

来源：植物  |  远志科  |  远志

In Vitro: Tenuifoliside A (6-30 μM; 24 hours) increases the C6 cells viability significantly by concentration dependent manner. But the viability of the 60 μM treatment group is suppressed. Only 60 μM TFSA induced the release of LDH, shows a toxic effect.
Tenuifoliside A (10 μM; 2, 5, 7, 10, 15, 30, 45 and 60 mins) elicits a rapid (starting at 2 min) and marked induction of ERK1/2 phosphorylation peaking at 5 min. And,the enhanced levels of phospho-ERK induced by TFSA are partially blocked by ERK inhibitor U0126.

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