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CAS No. : 88206-46-6
MCE 国际站:Notopterol
产品活性:Notopterol 是从 N. incisum 提取的香豆素。Notopterol 诱导细胞凋亡,具有解热,缓解疼痛和抗炎作用。Notopterol 有用于急性髓细胞性白血病 (AML) 的潜力。
研究领域:Apoptosis
作用靶点:Apoptosis
结构分类:苯丙素类 | 香豆素
来源:植物 | 伞形科 | 羌活
In Vitro: notopterol (5, 10, 20, 40, 60 μM; for 48 hours) promotes cell apoptosis in a dose-dependent manner.
notopterol (10, 20, 40, 60 and 80 μM; 24-120 hours) inhibits the proliferation of HL-60 cells in a concentration-dependent manner.
Notopterol (5, 10, 20 and 40 μM; for 48 hours) induces G0/G1 phase arrest associated with cell-cycle proteins in HL-60 cells.
Notopterol (5, 10, 20 and 40 μM; for 48 hours) increases the expression of Bax and decreased the expression of Bcl-2 and Mcl-1 in HL-60 cells after 48-hr treatment. Moreover, Notopterol also promotes the cleavage of caspase 9, caspase 3 and PARP.
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货号: HY-N0564
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