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CAS No. : 3131-52-0
MCE 国际站:5,6-Dihydroxyindole
产品活性:5,6-Dihydroxyindole 是一种黑色素的前体,具有广谱抗菌,抗真菌,抗病毒,抗寄生虫活性。5,6-Dihydroxyindole 具有细胞毒性作用,并且对各种病原体具有强毒性。
研究领域:Anti-infection | Metabolic Enzyme/Protease
作用靶点:Bacterial | Fungal | Parasite | Endogenous Metabolite
结构分类:酚类 | 多酚类 | 其他类
In Vitro: 5,6-Dihydroxyindole (1, 10, 20, 50, 100 μM; for 4 hours) dose-dependently decreases OD492 values. Pretreatment of Sf9 cells with 1.0 mM 5,6-Dihydroxyindole for 4 hours results in 97% mortality, and LC50 values of 20.3 μM in buffer and 131.8 μM in a culture medium.
Preincubation of a baculovirus stock with 1.25 mM 5,6-Dihydroxyindole for 3 hours near fully disables recombinant protein production. The LC50 for lambda bacteriophage and eggs of the wasp Microplitis demolitor are 5.6 and 111.0 μM, respectively.
5,6-Dihydroxyindole and its spontaneous oxidation products are also active against viruses and parasitic wasps.
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