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CAS No. : 18883-66-4
MCE 国际站:Streptozotocin
产品活性:Streptozotocin (Streptozocin) 是一种抗生素,可使 DNA 甲基化 (DNA-methylating) 。Streptozotocin 引起肝脏,肾脏及胰腺 DNA 甲基化,但脑 DNA 中没有甲基化。
研究领域:Cell Cycle/DNA Damage | Autophagy | Anti-infection
作用靶点:DNA/RNA Synthesis | DNA Alkylator/Crosslinker | Autophagy | Bacterial | Antibiotic
结构分类:抗生素 | 疾病研究 | 抗癌 | 抗生素 | 其他类 | 抗生素 | 哺乳动物细胞培养 | 结构分类
In Vitro: Streptozotocin (STZ) shows higher cytotoxic effect in vitro on hematological cell lines compared to Alloxan (ALX). ALX appeares not to be toxic for the studied cell lines with estimated IC50 values of 2809, 3679 or over 4000 μg/mL for HL60, K562 and C1498 cells, respectively. Streptozotocinn is more toxic, especially for the human myeloid leukemia cell line, HL60. The IC50 values of Streptozotocin are 11.7, 904 and 1024 μg/mL for HL60, K562 and C1498 cells, respectively. Results also show that the murine leukemic cells are more resistant to Streptozotocin and ALX cytotoxicity than human leukemic cells.
In Vivo: Streptozotocin can be used in animal modeling to establish rat and mouse models of diabetes.
Streptozotocin (STZ)-injected mice show tendency to have lower body weight than that observed in animals injected with ALX. Streptozotocin -injected mice have significantly fewer splenocytes (22.2±3.2×106; n=10) compared to mice injected with ALX (60.7±4.3×106; n=15; p=0.01).
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货号: HY-13753
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