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Guanidine hydrochloride

CAS No. : 50-01-1

MCE 国际站：Guanidine hydrochloride

产品活性：Guanidine hydrochloride (Guanidinium chloride) 是一种强离液剂，也是一种蛋白质的强变性剂。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

结构分类：其他类

In Vitro: Guanidine hydrochloride at low concentrations refolds acid-unfolded apomyoglobin and cytochrome c, stabilizing the molten globule state, i.e. a compact denatured state with a significant amount of secondary structure, but substantially disordered tertiary structure. Guanidine hydrochloride (> 1 M) causes co-operative unfolding of the molten globule state.
A considerable degree of ordered structure remains due to the presence of disulfide bonds, which Guanidine hydrochloride does not affect.
Guanidine hydrochloride at millimolar concentrations, is able to causes efficient loss of the normally stable [PSI⁺] element from yeast cells. 5 mM Guanidine hydrochloride in growth media cures [PSI⁺] and other prions of yeast. 5 mM Guanidine hydrochloride significantly reduces Hsp104-mediated basal and acquired thermotolerance by 30-fold and 50 fold, respectively. Guanidine hydrochloride also reduces the ability of Hsp104 to restore activity of thermally denatured luciferase.

In Vivo: A significant reduction in the death rate of infant mice infected with ten LD₅₀) of coxsackievirus A16 is observed when they are treated 58 h after infection with two injections of Guanidine hydrochloride at 145 mg/kg per injection.

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