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CAS No. : 52-67-5
MCE 国际站:Penicillamine
产品活性:Penicillamine (D-(-)-Penicillamine) 是 penicillin 的代谢降解产物,可作为重金属螯合剂使用。Penicillamine 增加游离铜,增强氧化应激。Penicillamine 通过 NO/NMDA 途径对癫痫发作起作用。Penicillamine 是一种潜在的免疫调节剂。青霉胺可用于威尔逊氏病、类风湿关节炎和半胱氨酸尿症的研究。
研究领域:Metabolic Enzyme/Protease
作用靶点:Drug Metabolite
结构分类:酮、醛、酸
In Vitro: Penicillamine (D-(-)-Penicillamine) (5 mg; 7 d; CD4+ and CD+ splenocytes) promotes cellular immune responses.
In Vivo: Penicillamine (D-(-)-Penicillamine) (200 mg/kg; i.g.; daily, for 3, 10 and 14 d; tx mice and DL mice) increases serum free copper concentration.
Penicillamine (200 mg/kg; i.g.; daily, for 3, 10 and 14 d; tx mice and DL mice) increases ATP7A and CTR1 mRNA expression in the brain of tx mice.
Penicillamine (200 mg/kg; i.g.; daily, for 3, 10 and 14 d; tx mice and DL mice) induces oxidative-stress in the central nervous system.
Penicillamine (0.1-250 mg/kg; i.p.; once, for 90 min; male NMRI mice) has binaural phase effect on seizure.
Penicillamine (5 mg/kg; i.v.; daily, for 8 weeks; male BN rats) prevents the onset of autoimmunity at a low dose.
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