MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Quinine hydrochloride dihydrate

CAS No. : 6119-47-7

MCE 国际站：Quinine hydrochloride dihydrate

产品活性：Quinine hydrochloride dihydrate 具有口服活性，可用作抗疟疾研究。Quinine hydrochloride dihydrate 是一种钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (K_Ca5.1) 通道 +100 mV 电流, 其 IC₅₀ 值为 169 μM。

研究领域：Anti-infection  |  Membrane Transporter/Ion Channel

作用靶点：Parasite  |  Potassium Channel

结构分类：生物碱  |  喹啉类生物碱  |  结构分类

来源：植物  |  茜草科  |  金鸡纳树

In Vitro: Quinine hydrochloride dihydrate (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line.
?Quinine hydrochloride dihydrate (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line.

In Vivo: Quinine hydrochloride dihydrate (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice.
?Quinine hydrochloride dihydrate (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats.

相关产品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  Natural Product Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Alzheimer's Disease Compound Library  |  Alkaloids Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Antiparasitic Compound library  |  Neurodegenerative Disease-related Compound Library  |  Food Additive Library   |  Children’s Drug Library  |  Plant-Sourced Natural Product Library  |  Potassium Channel Compound Library  |  Human Metabolite Library  |  Heterocyclic Compound Library  |  Off-patent Drug Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Antifungal agent 26  |  Mitiglinide-d₅ calcium  |  Quinidine-d₃  |  Angulatin G  |  Acridine Orange base  |  N-Desethyl amodiaquine-d₅  |  Palitantin  |  Proguanil-d₆  |  Azlocillin sodium salt  |  Methyl palmitate  |  Ropivacaine hydrochloride  |  HBPC–GSH  |  Doxycycline calcium  |  WX-081  |  SQ109  |  13,21-Dihydroeurycomanone  |  Nevirapine  |  Monensin sodium salt  |  Doxapram hydrochloride hydrate  |  Clindamycin phosphate  |  1-Deacetylnimbolinin B  |  KDU731  |  (E)-Fenpyroximate  |  Niclosamide monohydrate  |  Antimalarial agent 8  |  TASK-1-IN-1  |  Geranin A  |  Cabamiquine  |  Harpagide

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-B0433A

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。