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Arctigenin

CAS No. : 7770-78-7

MCE 国际站：Arctigenin

产品活性：Arctigenin ((-)-Arctigenin) 是一种具有生物活性的木脂素，可用作抗肿瘤剂。Arctigenin 具有有效的抗氧化、抗炎和抗病毒 (influenza A virus) 活性。Arctigenin 可用于代谢紊乱和中枢神经系统功能障碍的研究。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection  |  Autophagy  |  Apoptosis

作用靶点：MMP  |  Influenza Virus  |  Autophagy  |  Apoptosis

结构分类：苯丙素类  |  木脂素

来源：植物  |  豆科  |  大叶南天藤  |  植物  |  菊科

In Vitro: Arctigenin (0.01-1 μg/mL; 0.5-24 h) shows preferential cytotoxicity against the PANC-1 cell line under nutrient-deprived conditions in a concentration- and time-dependent manner.
Arctigenin (0.01-1 μg/mL; 0.5-24 h) inhibits the survival of various cancer cell lines (ASPC-1, BXPC-3, Alexander, and PSN-1 cells) under nutrient-deprived conditions.
Arctigenin (0.1-1 μg/mL; 24 h) completely inhibits Akt phosphorylation stimulated by glucose deprivation in PANC-1 cells.
Arctigenin (5-25 μM) shows potent in vitro antiviral activities (IC₅₀=2.9 μM) against influenza A virus.

In Vivo: Arctigenin (250 μg/mL; 0.2 mL; i.p. 6 times a week for 9 weeks) suppress the PANC-1 tumor growth in nude mice.
Arctigenin (10 mg/kg; i.p. daily for 30 days) relieves experimental autoimmune encephalomyelitis (EAE) symptoms of mice.

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