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Aegeline

CAS No. : 456-12-2

MCE 国际站：Aegeline

产品活性：Aegeline 是一种主要生物碱，模拟酵母 SNARE 蛋白 Sec22p 抑制酵母 α-突触核蛋白和 Bax 毒性。Aegeline 恢复 αsyn 或 Bax 抑制的酵母细胞生长。

研究领域：Anti-infection

作用靶点：Fungal

结构分类：生物碱

来源：植物  |  芸香科  |  木橘

In Vitro: Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein orBax-expressing cells.
Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin.

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货号: HY-W042156

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