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CAS No. : 14101-61-2
MCE 国际站:γ-Tocotrienol
产品活性:γ-Tocotrienol 是维生素 E 的一种活性形式。γ-Tocotrienol 能够作用 NF-κB 和 P-gp 信号通路来逆转乳腺癌细胞多药耐药性 (MDR)。γ-Tocotrienol 也是一种新型的放射性保护剂,可减轻放射性核素靶向治疗时对骨髓的辐射损伤。
研究领域:Metabolic Enzyme/Protease | NF-κB
作用靶点:Endogenous Metabolite | NF-κB
结构分类:酚类 | 单酚类 | 结构分类
来源:植物 | 其他科
In Vitro: γ-Tocotrienol (25 μM; 24 h) effectively inhibits the expression levels of mdr1 mRNA and P-gp protein, (25 μM and 50 μM; 24 h) suppresses mdr1 promoter activity and the efflux activity of P-gp as well.
γ-Tocotrienol (25 μM and 50 μM; 24 h) reduces the activation of NF-κB signaling pathway and the transcriptional activity of NF-κB.
γ-tocotrienol (50 μM; 48 h) effectively inhibits the process of nuclear translocation of p65 which was induced by TNFα.
In Vivo: γ-Tocotrienol’s liposomal formulation, GT3-Nano (20 mol% γ-Tocotrienol), (10 mg/kg, 6 mol%; i.v.; single dose, observed for 100 d) is highly effective in mitigating the marrow-suppressive effects of sublethal and lethal TBI in mice.
GT3-Nano (50 mg/kg; i.v.; ) can facilitate rapid recovery of hematopoietic components in mice treated with the endoradiotherapeutic agent 153Sm-EDTMP.
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货号: HY-108694
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