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Neocryptotanshinone

CAS No. : 109664-02-0

MCE 国际站：Neocryptotanshinone

产品活性：Neocryptotanshinone 是从丹参 (Salvia Miltiorrhiza) 分离得到的一种丹参二萜，通过抑制 NF-κB 和 iNOS 信号来抑制脂多糖 (LPS) 诱导的炎症。

研究领域：NF-κB  |  Immunology/Inflammation

作用靶点：NF-κB  |  NO Synthase

结构分类：萜类  |  二萜  |  醌类  |  萘醌类  |  结构分类

来源：植物  |  菊科  |  泥胡菜  |  植物  |  唇形科

In Vitro: Neocryptotanshinone exhibits anti-inflammatory effect by suppression of NF-κB and iNOS signaling pathways.
Neocryptotanshinone (10 μM and 20 μM, 24 h) inhibits LPS-induced iNOS protein expression in RAW264.7 cells.
Neocryptotanshinone (20 μM, 24 h) shows no obvious cytotoxic effect towards murine RAW264.7 macrophages.

In Vivo: Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components).

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