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CAS No. : 275801-62-2
MCE 国际站:GLP-2(3-33)
产品活性:GLP-2(3-33) 由二肽基肽酶 IV (DPPIV) 产生,是一种 GLP-2 受体部分激动剂 (EC50=5.8 nM)。
研究领域:GPCR/G Protein
作用靶点:GCGR
In Vitro: GLP-2 is secreted as a 33-amino acid peptide, but is rapidly degraded at an N-terminus site to GLP-2(3-33) in circulation, in large part, by dipeptidylpeptidase IV (DPPIV). GLP-2 (3-33) acts as a partial agonist with potential competitive antagonistic properties on the GLP-2 receptor. In the GLP-2 receptor-binding assay, the binding IC50 for GLP-2 1–33 was 3.1 nM, and it was 41 nM for GLP-2 3-33. Thus, GLP-2 3–33 had 7.5% binding affinity compared to GLP-2 1-33.
In Vivo: GLP-2(3-33) (60 ng; once a day i.p. for 4 weeks) increases dyslipidemia and hepatic lipid accumulation in HFD-fed mice.
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