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CAS No. : 5995-86-8
MCE 国际站:Gallic acid hydrate
产品活性:Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate 是一种天然多羟基酚类化合物,具有抑制环氧合酶-2 (COX-2) 的自由基清除作用。Gallic acid hydrate 具有多种活性,如抗菌、抗氧化、抗菌、抗炎和抗肿瘤活性。
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Apoptosis
作用靶点:COX | Reactive Oxygen Species | Apoptosis | Ferroptosis | Endogenous Metabolite
结构分类:酚类 | 多酚类
来源:植物 | 其他科
In Vitro: Gallic acid is an antioxidant which can inhibit both COX-2. After 18 h treatment with Gallic acid, the number of viable neutrophils is dramatically decreased from 40.3% to 27.7%, highly comparable with 26.4% for untreated neutrophils. Gallic acid fails to attenuate isoproterenol-induced myocytolysis.
In Vivo: The food intake (2.6±0.08 g/day, p=0.69) and the body weight (2.5±0.69 g, p=0.76) of the Gallic acid group do not differ significantly from those of the control group (food intake; 2.41±0.14 g/day and the body weight; 2.83±0.84 g/day). The blood glucose tolerance in the Gallic acid group is significantly improved after 2 weeks of treatment. The blood glucose tolerance of the Gallic acid group after a treatment period of 2 weeks is also significantly better than that of the control group at 90 and 120 min ( p<0.05). The serum triglyceride concentration in the Gallic acid group (0.67±0.03 mM, p<0.05) is significantly reduced relative to that of the control group (1.08±0.20 mM). The total cholesterol concentration is similar in the control (3.19±0.27 mM) and Gallic acid (3.01±0.18 mM) groups.
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货号: HY-N0523A
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