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Oxindole

CAS No. : 59-48-3

MCE 国际站：Oxindole

产品活性：Oxindole (Indolin-2-one) 是芳族杂环砌块。 Oxindole衍生物已成为激酶抑制剂研究中的主要化合物。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：HIV  |  Endogenous Metabolite

结构分类：生物碱  |  吲哚类生物碱  |  结构分类

来源：植物  |  其他科

In Vitro: Oxindole (Indolin-2-one) is a bicyclic structure consisting of a benzene ring fused to 2-pyrrolidone. Substituted indolinones can be referred as ‘privileged structures’ owing to their excellent binding affinity for many receptors and to the number of approved drugs containing this scaffold. Oxindole has been found in tissues and fluids of mammals as well as natural products produced by a range of plants, bacteria and invertebrates. 2-indolinone derivatives possess diverse range of pharmacological activities including anti-cancer, anti-HIV, anti-diabetic, antibacterial, antioxidant, kinase inhibitory, AChE inhibitory, anti-leishmanial, b3 adrenergic receptor agonistic, phosphatase inhibitory, analgesic, spermicidal, vasopressin antagonists, progesterone antagonists, neuroprotection, NMDA blocker and sleep inducing activities.

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