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Pterostilbene

CAS No. : 537-42-8

MCE 国际站：Pterostilbene

产品活性：Pterostilbene 是从蓝莓和囊状紫檀中得到的芪类化合物，具有抗氧化、抗炎、抗癌、抗糖尿病和抗肥胖等功效。Pterostilbene 抑制 ROS 的生成，能对抗多种自由基，例如 DPPH，ABTS，hydroxyl，superoxide 和 hydrogen peroxide 等。

研究领域：Autophagy

作用靶点：Autophagy

结构分类：酚类  |  单酚类  |  二苯乙烯类  |  结构分类

来源：植物  |  其他科

In Vitro: Pterostilbene (0, 5, 25, 50, 100, 200 and 400 µM) shows inhibitory activity against the growth of HeLa cells, with IC₅₀s of 101.2 µM and 65.9 µM at 24 and 48 hrs, respectively. Ipterostilbene (0, 25, 100 and 200 µM) also induces the apoptosis HeLa cells.
Pterostilbene (0.05, 0.1, 0.15 and 0.2 mM) has high anti-oxidant activity against DPPH, ABTS, hydroxyl, superoxide, hydrogen peroxide in a dose-dependent manner. Pterostilbene decreases lipid peroxides and hydroperoxides, reduces protein carbonyl groups and restores protein sulphydryl groups in response to damage by TBHP and As-Fe²⁺. Pterostilbene also inhibits single strand breaks in pBR322.

In Vivo: Pterostilbene (30 mg/kg daily, p.o. for 21 days) inhibits reactive oxygen species production in the animal model of inflammation.

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