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CAS No. : 93-07-2
MCE 国际站:Veratric acid
产品活性:Veratric acid (3,4-Dimethoxybenzoic acid) 是从蔬菜和水果中得到的多酚物质,可口服,具有抗氧化、保护心血管和抗炎活性。当细胞受到 UVB 辐射时,Veratric acid 能够减少上调的 COX-2 表达,降低 PGE2 和 IL-6 水平。
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
作用靶点:COX | Reactive Oxygen Species
结构分类:酮、醛、酸
来源:植物 | 其他科
In Vitro: Veratric acid (100, 200 μM) suppresses iNOS expression in LPS-stimulated RAW264.7 cells. Veratric acid (200 μM) inhibits LPS-induced activation of the PI3K/Akt pathway, HAT activation and HDAC3 expression in RAW264.7 cells.
Veratric Acid (10-100 μg/mL) has anti-inflammatory activity, protects HaCaT cells against UVB-mediated phototoxicity, increases S-phase cells, and prevents UVB-mediated apoptosis.
Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.
In Vivo: Veratric acid (40 mg/kg, p.o., b.w.) significantly promotes ventricular function, reduces lipid peroxidation and increases antioxidants in l-NAME-induced hypertensive rats.
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货号: HY-N2007
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