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CAS No. : 59870-68-7
MCE 国际站:Glabridin
产品活性:Glabridin 是从 Glycyrrhiza uralensis 中分到的异黄烷类,能够结合并激活 PPARγ,EC50 值为 6115 nM。Glabridin 具有抗氧化、抗菌、抗肾炎、抗糖尿病、抗肿瘤、抗炎、抗骨质疏松、保护心血管、保护神经、清除自由基等作用。
研究领域:Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor | Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Anti-infection
作用靶点:PPAR | Reactive Oxygen Species | Bacterial
结构分类:黄酮类 | 异黄酮 | 酚类 | 多酚类 | 结构分类
来源:植物 | 豆科 | 甘草
In Vitro: Glabridin binds to and activates PPARγ, with an EC50 of 6115 nM.
?Glabridin (40, 80 μM) inhibits the proliferation of SCC-9 and SAS cell lines in a dose- and time-dependent manner after treatment for 24 and 48 h.
?Glabridin (0-80 μM) also induces apoptosis, causes Sub-G1 cell cycle arrest in SCC-9 and SAS cell lines.
?Glabridin (0, 20, 40, and 80 μM) dose-dependently activates caspase-3, ?8, and ?9 and increases PARP cleavage, significantly phosphorylates ERK1/2, JNK1/2, and p-38 MAPK in SCC-9 cells.
In Vivo: Glabridin (50 mg/kg, p.o. once daily) shows potent anti-inflammatory activity, ameliorates the inflammatory alterations induced by Dextran sodium sulphate (DSS) in rats.
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货号: HY-N0393
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