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Jaceosidin

CAS No. : 18085-97-7

MCE 国际站：Jaceosidin

产品活性：Jaceosidin 是从 Artemisia vestita 中得到的黄酮类化合物，可激活 Bax，下调 Mcl-1 和 c-FLIP 的表达，诱导癌细胞凋亡。Jaceosidin 具有抗癌和抗炎作用，能够降低炎性因子水平，激活 NF-κB，抑制 COX-2 的表达。

研究领域：Apoptosis  |  Immunology/Inflammation

作用靶点：Bcl-2 Family  |  COX  |  Apoptosis

结构分类：黄酮类  |  黄酮  |  酚类  |  多酚类  |  结构分类

来源：植物  |  豆科  |  毒豆  |  植物  |  菊科

In Vitro: Jaceosidin (30, 50, 75 μM) induces apoptosis in human renal carcinoma Caki cells after treatment for 24 h, shows no obvious effect on normal cells.
?Jaceosidin (75 μM) reduces MMP levels and causes cytochrome c release into the cytoplasm through Bax activation.
?Jaceosidin-mediated apoptosis is involved in downregulation of Mcl-1, c-FLIP expression, which is via inhibition of NF-κB and/or Sp1 transcriptional activity.
?Jaceosidin shows cytostatic activity to HES and HESC cells with IC₅₀s of 52.68 and 55.10 μM, and is less cytotocxic on Hec1 A and KLE (IC₅₀, 70.54, 147.14 μM, respectively), after treatment for 48 h.

In Vivo: Jaceosidin (10 and 20 mg/kg, p.o., once a day for 3 days) blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates in mice.
?Jaceosidin (10, 20 mg/kg, p.o.) suppresses COX-2 expression and NF-κB activation in mice.
?Jaceosidin (20 mg/kg, p.o. for 2 hours) reduces hind paw edema volume in rats.

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货号: HY-N0831

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