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CAS No. : 142846-71-7
MCE 国际站:Galanin Receptor Ligand M35
产品活性:Galanin Receptor Ligand M35 是一种高亲和力的甘丙肽受体 (galanin receptor) 配体 (Kd=0.1 nM),也是 galanin receptor 拮抗剂。Galanin Receptor Ligand M35 对人甘丙肽受体 1 型 和 人甘丙肽受体 2 型 的 Ki 值分别为 0.11 nM、2.0 nM。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Neuropeptide Y Receptor
In Vitro: Galanin Receptor Ligand M35 has a dual effect on the galanin mediated inhibition of Forskolin stimulated cyclic AMP production in Rin m 5F cells. Co-applied with galanin (10 nM), Galanin Receptor Ligand M35 at low concentrations (1 nM) is able to reverse the inhibitory effect of galanin. But when present at higher concentrations (15 and 30 nM), Galanin Receptor Ligand M35 acts as a galanin receptor agonist, inhibiting the forskolin stimulated production of cAMP.
In Vivo: Galanin Receptor Ligand M35 (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task.
相关产品:Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Endocrinology Compound Library | Neurotransmitter Receptor Compound Library | Anti-Obesity Compound Library | Targeted Diversity Library | Peptide Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Neuropeptide Y (3-36) (porcine) | CART(55-102)(rat) | Galanin (1-16), mouse, porcine, rat | RFRP-1(human) TFA | Spexin | Galanin Receptor Ligand M35 TFA | RFRP-1(human) | CART(55-102)(human) | RTI-118 | RF9 | [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA | SF 11 | RFRP-3(human) TFA | M1145 TFA | (Leu31,Pro34)-Peptide YY (human) | Galantide | CYM 9484 | Neuropeptide Y (18-36) (porcine) | Neuropeptide Y (human) (TFA) | NTNCB hydrochloride | M40 | Neuropeptide S(Rat) TFA | FR252384 | BIBP3226
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