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ACTH (1-17) (TFA)

CAS No. :

MCE 国际站：ACTH (1-17) (TFA)

产品活性：ACTH (1-17) TFA 是促肾上腺皮质激素类似物，是一种有效的人黑皮素受体 (human melanocortin 1 (MC1) receptor) 激动剂，K_i 值为 0.21 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Melanocortin Receptor

In Vitro: ACTH (1-17) TFA is a potent agonist at the hMC1R. ACTH (1-17) shows high affinity for the hMC1R with a K_i value of 0.21±0.03 nM which is slightly higher than that of 0.13±0.005 nM for alpha-MSH. ACTH (1-17) induces a slight and not significant increase in growth hormone secretion even when micromolar concentrations of the peptide are employed in rat pituitary cultures.

In Vivo: Inhibition of DNA labeling is noted when the ACTH (1-17) is administered at 2 hr after the beginning of the daily dark span when nocturnal animals become active. When administered at this circadian stage, the larger dose in particular is associated with an inhibition of DNA labeling lasting for 24 hr. The inhibitory effect is much shorter when the same dose is injected 4 hr earlier.

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