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CAS No. : 58479-68-8
MCE 国际站:Platycodin D
产品活性:Platycodin D 是可从桔梗中分离得到的皂苷类化合物,为 AMPKα 的激活剂,具有抗肥胖活性。WNT/β-catenin 通路介导 Platycodin D 的抗成脂作用。
研究领域:Epigenetics | PI3K/Akt/mTOR | Stem Cell/Wnt
作用靶点:AMPK | Wnt
结构分类:萜类 | 三萜 | 结构分类
来源:植物 | 桔梗科 | 桔梗
In Vitro: Platycodin D (4 μM; 24 h) increases gene expressions of Ucp1, Pgc1a, Sirt3, Cytc, Nrf1 and Prdm16, and suppresses expressions of adipokine genes Fabp4, Adipoq, Lipin1 in 3T3-L1 adipocytes and FABP4, ADIPOQ and RESISTIN in hAMSCs.Platycodin D (2 and 10 μM) suppresses lipid accumulation in murine and human adipocytes respectively.Platycodin D suppresses the protein expressions of PPARγ and C/EBPα, and increases protein expressions of UCP1, PGC1α, SIRT3, CIDEA and LIPIN1.Platycodin D (10 μM) inhibits lipid droplet formation, and reduces the expression of the FABP4 protein involved in lipid metabolism and the expressions of PPARγ and C/EBPα.Platycodin D (10 μM; 0-7 d) recoveres CCND1 mRNA level and increases PPARδ level.
In Vivo: Platycodin D (5 mg/kg; oral administration, 5 times per week for 5 weeks) decreases the body weight of obese mice.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Epigenetics Compound Library | Kinase Inhibitor Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Natural Product Library | Anti-Aging Compound Library | Antioxidant Compound Library | Glycoside Compound Library | Oxygen Sensing Compound Library | Medicine Food Homology Compound Library | Terpenoids Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Traditional Chinese Medicine Active Compound Library | Neuroprotective Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Lipid Metabolism Compound Library | Glucose Metabolism Compound Library | Plant-Sourced Natural Product Library | Pain-Related Compound Library | FzM1 | ZLN024 | YLF-466D | Pamidronic acid | Fz7-21 | Nepodin | AMPK activator 9 | NSC668036 | JW67 | Ipafricept | Ipivivint | WIC1 | Metformin-d6 hydrochloride | AMPK-IN-3 | HTH-01-015 | AMARA peptide TFA | JW74 | IQ 1 | Heparan Sulfate | LRRK2/NUAK1/TYK2-IN-1 | L-Quebrachitol | ETC-159 | HLY78 | AMPK-IN-1 | AICAR | Metformin | BC1618 | BAY-3827 | Cardiogenol C hydrochloride | Demethyleneberberine chloride
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货号: HY-N1411
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